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Affymetrix Pte
Ltd
Contact:
No. 7 Gul Circle
#2M-01/08. Keppel Logistics Building
Singapore 629563
Tel: (65) 6395-7200
Fax: (65) 6395-7300
E-mail: [email protected]
Website:
www.affymetrix.com Categories: Microarray Systems, Genetic Research,
Pharmaceuticals, Biotechnology Products, Ribonucleic Acid
Extraction Kits Company Profile: Affymetrix Inc manufactures products
for genetic research including
diagnostic tools and microarray systems for genome
elucidation
Affymetrix (AFFX) is a pioneer in creating
breakthrough tools that are driving the genomic
revolution. The vision, innovation, and devotion of
Affymetrix employees help us empower scientists
around the world to alleviate human suffering. It is
not just the sheer power of GeneChip? technology
that inspires us; it is the potential for it to help
people.
Affymetrix Inc was one of the pioneering companies
in genetic microarray technology in the 1980s. It
now manufactures products for genetic research
including diagnostic tools and microarray systems
for genome elucidation. DNA microarrays are
high-throughput technology used for research in
molecular biology and medicine in identifying and
measuring genetic information associated with
complex diseases and testing potential drugs.
The technology involves devices with thousands of
arrayed microscopic spots of DNA oligonucleotides,
each containing picomoles of specific DNA sequence.
The arrayed DNA sequences are used as probes to
analyse cDNA or cRNA samples under highly stringent
conditions. The hybridised probes are usually
detected using fluorescence detection to give
qualitative and quantitative results of nucleic acid
sequences in the target sample (identification and
quantification).
For the microarrays the DNA probes are covalently
bonded to a solid surface using a chemical matrix
(various silanes or polyacrylamide). The solid
surface in the case of Affymetrix GeneChips is
quartz glass (5in square chips).
Affymetrix quartz GeneChips using oligonucleotide
microarrays are used for scanning for the presence
of particular genes in biological samples. The
microarrays are used on a single chip to carry out
thousands of gene screening experiments in parallel.
In May 2007 Affymetrix opened its new manufacturing
facility in Singapore. This is the company's first
manufacturing facility located outside the US and
has raised speculation about the company expanding
to an area where the costs of manufacturing are much
less.
March 2008 saw 23 job cuts at Sacramento and a
statement about manufacturing transfer to Singapore
being carried out in three phases (up to 40% of
manufacturing volume). The consolidation is not
expected to affect chemical reagent, instrument and
logistics functions at the Sacramento plant, which
was also expanded in 2006–2007.
Kevin King, president of life sciences business and
executive vice president at Affymetrix, commented:
"While Singapore offers a number of significant
economic, political and lifestyle advantages,
Affymetrix was most impressed with the country's
commitment and support to the life sciences
industry. In fact, a number of our most innovative
and highly valued customers are here in Singapore,
doing research in everything from cancer to
population genetics to diabetes... This new facility
enables us to better serve and support our growing
customer base around the world."
The new Affymetrix Singapore facility is located at
the Keppel Logistics Building at Gul Circle, Jurong
Industrial Park. The facility has been operational
since the end of 2006 and now employs 120 staff
members. The facility was designed to look and
operate like the company's main manufacturing
facility in Sacramento.
"There are now more than 20 different molecular
assay tests based on the Affymetrix platform under
development by Affymetrix and its 11 PbA
partners."Affymetrix has partnered with eleven
different partners, powered by Affymetrix (PbA), to
provide technology for diagnostic tests. One of the
most recent agreements was with the French company
Ipsogen for its Ipsogen MapQuant Dx Genomic Grade
tumour grading test.
Tumour grade is one of the key indicators of
malignancy and a more accurate measurement is a help
to oncologists making decisions about treatment.
Grade-3 tumours require chemotherapy, while grade-1
tumours are only treated with hormonotherapy.
Traditional grading techniques show 50% of tumours
classified in the intermediate grade-2 category,
making treatment decisions problematic.
The MapQuant Dx Genomic Grade is a molecular test to
grade breast carcinomas based on a 97-gene
expression signature of the tumour. The use of this
test provides a more precise and accurate grading
measurement. There are now more than 20 different
molecular assay tests based on the Affymetrix
platform under development by Affymetrix and its 11
PbA partners.
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